Clinical characteristics of 99 patients hospitalized with pneumonia due to Coronavirus infection 2019, from March 15 to May 31, 2020
Keywords:
SARS-CoV-2, COVID-19, Risk factors, clinical characteristicsopñ
Abstract
Introduction: At the end of 2019, a new coronavirus was identified as a cause of cases of isolated pneumonia in Wuhan, a city in Hubei province of China, this rapid expansion soon reached pandemic levels, affecting the world. In February 2020, the World Health Organization designated the virus that causes SARS. CoV-2 (Severe Acute Respiratory Syndrome) (1), as COVID-19.
Various observational studies have been carried out since the beginning of the pandemic, reporting clinical manifestations that include fever, non-productive cough, dyspnea, myalgia, fatigue, leukopenia, and radiological evidence of Pneumonia, later a tendency to develop serious disease in adults was reported older male (2).
Objectives: The objective of this series of cases was to describe the clinical characteristics of the first 99 patients with Pneumonia with COVID-19 infection, and to compare the evolution of the cases according to the management implemented.
Materials and Methods: report and description of a series of cases
Results: Describe the clinical characteristics of an urban rural Ecuadorian population with COVID-19 Pneumonia.
Conclusion: An average age of 58 years was found, 51.5% (51 patients) were women, of these 13.1% (13 patients) were referred to Intensive Care or required mechanical ventilation, a total of 55.6 % (55) patients were discharged home, with an overall hospital mortality of 17.2%.
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References
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25. Bilaloglu S, Aphinyanaphongs Y, Jones S, Iturrate E, Hochman J, Berger JS. Thrombosis in Hospitalized Patients with COVID-19 in a New York City Health System. JAMA - J Am Med Asso. 2020. doi:10.1001/jama.2020.13372.
26. Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report. N Engl J Med. julio 2020:NEJMoa2021436. doi:10.1056/NEJMoa2021436
27. Richardson S,HirschJS,NarasimhanM, etal; the Northwell COVID-19 Research Consortium. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020; 323(20):2052-2059. doi:10.1001/jama.2020.6775.
28. Garg S,Kim L,Whitaker M,etal. Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirusdisease 2019—COVID-NET, 14 States, March 1-30, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(15):458- 464. doi:10.15585/mmwr.mm6915e3.
29. Karagiannidis C, Mostert C, Case characteristics, resources use, and outcomes of 10021patients with COVID-19 admitted to 920 observational study, the lancet Respiratory Mdedicine. 2020 vol.8(9)pp.853-862.
2. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA - J Am Med Assoc. 2020;323(11):1061–1069. doi:10.1001/jama.2020.1585
3. WHO-2019-nCoV-clinical-2020.4-eng.
4. Ranieri VM, Rubenfeld GD, Thompson BT, et al. Acute respiratory distress syndrome: The Berlin definition. JAMA - J Am Med Assoc. 2012;307(23):2526–2533. doi:10.1001/jama.2012.566.
5. Li Q, Guan X, Wu P, et al. early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. [published on January 29, 2020]. N Engl J Med. 2020. doi:10. 1056/NEJMoa2001316.
6. Sanche, Steven RESEARCH High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2, Emerging Infectious Diseases, 2020.
7. Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020;18(5):1094–1099. doi:10.1111/jth.14817
8. Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 2020;20(6):363–374. doi:10.1038/s41577-020-0311-8
9. Debuc B, Smadja DM. Is COVID-19 a New Hematologic Disease? 2020. doi:10.1007/s12015-020-09987-4
10. Levi M, Thachil J, Iba T, Levy JH. Comment Coagulation abnormalities and thrombosis in patients with COVID-19. 2020. doi:10.1016/S2352-3026(20)30145-9
11. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease, 2019 in China. N Engl J Med 2020; 382: 1708–20
12. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033–1034. doi:10.1016/S0140-6736(20)30628-0
13. McGonagle D, O’Donnell JS, Sharif K, Emery P, Bridgewood C. Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia. Lancet Rheumatol. 2020;2(7):e437–e445. doi:10.1016/S2665-9913(20)30121-1
14. Ten VS, Pinsky DJ. Endothelial response to hypoxia: physiologic adaptation and pathologic dysfunction. Curr Opin Crit Care 2002; 8: 242–50.
15. Yan SF, Mackman N, Kisiel W, Stern DM, Pinsky DJ. Hypoxia/hypoxemia-induced activation of the procoagulant pathways and the pathogenesis of ischemia-associated thrombosis. Arterioscler Thromb Vasc Biol 1999; 19: 2029–35
16. Sandoval Y, Januzzi JL, Jaffe AS. Cardiac Troponin for the Diagnosis and Risk-Stratification of Myocardial Injury in COVID-19: JACC Review Topic of the Week. J Am Coll Cardiol. julio 2020. doi:10.1016/j.jacc.2020.06.068
17. Sandoval Y, Jaffe AS. Type 2 Myocardial Infarction: JACC Review Topic of the Week. J Am Coll Cardiol. 2019;73(14):1846–1860. doi:10.1016/J.JACC.2019.02.018
18. Moore JB, June CH. Cytokine release syndrome in severe COVID-19. Science 2020; 368: 473-474.
19. AlhazzaniW,MøllerMH, ArabiYM,etal. Surviving Sepsis Campaign: guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19). Intensive Care Med. 2020;46(5):854-887. doi:10.1007/s00134-020- 06022-5
20. Rawson TM, Moore LSP, Zhu N, et al. Bacterial and fungal co-infection in individuals with coronavirus: a rapid review to support COVID-19 antimicrobial prescribing. Clin Infect Dis. Published online May 2, 2020. doi:10.1093/cid/ciaa530
21. Magagnoli J, Narendran S, Pereira F, et al. Outcomes of hydroxychloroquine usage in United States veterans hospitalized with COVID-19. MedRxiv. Preprint posted June 5, 2020. doi:10.1016/j.medj.2020.06.001.
22. Mahévas M, Tran VT, Roumier M, et al. Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data. BMJ. 2020;369:m1844. doi:10.1136/bmj.m1844.
23. Rosenberg ES, Dufort EM, Udo T, et al. Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York State. JAMA. 2020;323(24):2493-2502. doi:10.1001/jama.2020. 8630.
24. ThachilJ,TangN,GandoS,etal. ISTHinterim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost. 2020;18(5):1023-1026. doi:10.1111/jth.14810.
25. Bilaloglu S, Aphinyanaphongs Y, Jones S, Iturrate E, Hochman J, Berger JS. Thrombosis in Hospitalized Patients with COVID-19 in a New York City Health System. JAMA - J Am Med Asso. 2020. doi:10.1001/jama.2020.13372.
26. Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report. N Engl J Med. julio 2020:NEJMoa2021436. doi:10.1056/NEJMoa2021436
27. Richardson S,HirschJS,NarasimhanM, etal; the Northwell COVID-19 Research Consortium. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020; 323(20):2052-2059. doi:10.1001/jama.2020.6775.
28. Garg S,Kim L,Whitaker M,etal. Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirusdisease 2019—COVID-NET, 14 States, March 1-30, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(15):458- 464. doi:10.15585/mmwr.mm6915e3.
29. Karagiannidis C, Mostert C, Case characteristics, resources use, and outcomes of 10021patients with COVID-19 admitted to 920 observational study, the lancet Respiratory Mdedicine. 2020 vol.8(9)pp.853-862.
Published
2020-11-22
How to Cite
1.
Proaño R. Clinical characteristics of 99 patients hospitalized with pneumonia due to Coronavirus infection 2019, from March 15 to May 31, 2020. PFR [Internet]. 2020Nov.22 [cited 2024Nov.8];5(3). Available from: https://practicafamiliarrural.org/index.php/pfr/article/view/182
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