Germline genomic edition: ethical dilemmas
Abstract
Germ cell genomic editing is a genetic engineering technique in which DNA is inserted, removed or replaced in the genome of gametes or precursor cells. In November 2018, the Chinese researcher He Jiankui, announced with his colleagues the "creation" of the world's first genetically modified babies through the CRISPR-Cas9 system, the Lulu and Nana twins. These statements generated different reactions in the scientific community, as well as questions about the bioethical dilemmas that involve these types of procedures.
The objective of this article is to analyze national and international consensus related to bioethical aspects in genomic editing research in humans.
Downloads
References
2. Li, J. R., Walker, S., Nie, J. B., & Zhang, X. Q. (2019). Experiments that led to the first gene-edited babies: the ethical failings and the urgent need for better governance. Journal of Zhejiang University-SCIENCE B, 20(1), 32-38.
3. Wang, C., Zhai, X., Zhang, X., Li, L., Wang, J., & Liu, D. P. (2019). Gene-edited babies: Chinese Academy of Medical Sciences’ response and action. The Lancet, 393(10166), 25-26.
4. Araki, M., & Ishii, T. (2014). International regulatory landscape and integration of corrective genome editing into in vitro fertilization. Reproductive biology and endocrinology, 12(1), 108.
5. Greely, H. T. (2019). CRISPR’d babies: human germline genome editing in the ‘He Jiankui affair’. Journal of Law and the Biosciences, 6(1), 111-183.
6. Nuffield Council in Bioethicis. (2018). Genome editing and human reproduction: social and ethical issues. Nuufield Coucil on Bioethics. Disponible en: https://nuffieldbioethics.org/assets/pdfs/Genome-editing-and-human-reproduction-report.pdf
7. Gyngell, C., Bowman-Smart, H., & Savulescu, J. (2019). Moral reasons to edit the human genome: picking up from the Nuffield report. Journal of medical ethics, 45(8), 514-523
8. Organización Mundial de la Salud (2018) WHO expert advisory committee on Developing global standards for governance and oversight of Human Genome editing. Disponible en: https://www.who.int/ethics/topics/human-genome-editing/committee-members/en/
9. UNESCO (2018) Grupo de expertos de la UNESCO pide la prohibición de "edición" del ADN humano para evitar inmoral manipulación de los rasgos hereditarios Disponible en: https://es.unesco.org/news/grupo-expertos-unesco-pide-prohibicion-edicion-del-adn-humano-evitar-inmoral-manipulacion
10. Organización Panamericana de la Salud (2006) LEY ORGANICA DE SALUD. Disponible en: https://www.paho.org/disasters/index.php?option=com_docman&view=download&category_slug=safehospitalslegislation&alias=1770-ley-organica-de-salud-2006&Itemid=1179&lang=en
11. Ministerio de Salud Publica (2019) BORRADOR PARA SEGUNDO DEBATE DEL PROYECTO DE CÓDIGO ORGÁNICO DE SALUD. Disponible en: https://www.salud.gob.ec/wpcontent/uploads/2018/05/COS_borrador_para_Segundo_debate-_marzo-2018.pdf
Copyright (c) 2019 Rural Family Practice
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
