Covid 19 update: outpatient therapy and variants
Keywords:
Covid-19, update March 2022, clinical guide
Abstract
An update of scientific medical knowledge about COVID-19 is carried out in relation to pharmacology, outpatient treatment, and variants.
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References
1. National Institutes of Health. Covid-19 Treatment Guidelines: What’s New in the Guidelines. Updated January 19, 2022. Accessed Feb 20, 2022 2022. https://www.covid19treatmentguidelines.nih.gov/about-the-guidelines/whats-new/
2. Mahase E. COVID-19: Pfizer’s paxlovid is 89% effective in patients at risk of serious illness, company reports. BMJ 2021; 375:n2713 DOI:10.1136/bmj.n2713. PMID 34750163
3.Gottlieb RL, Vaca CE, Paredes R, et al; GS-US-540-9012 (PINETREE) Investigators. Early remdesivir to prevent progression to severe Covid-19 in outpatients. N Engl J Med. Published online December 22, 2021. doi:10.1056/NEJMoa2116846 [PubMed 34937145]
4. Bernal AJ, Gomes da Silva MM, Musungaie DB, et al. Molnupiravir for oral Treatment of COVID-19 in non-hospitalized patients. N Engl J Med 2021. Published online ahead of print. DOI: 10.1056/MEJMoa2116044. PMID 34914868
5. Levin MJ, Ustianowski A, De Wit S, et al. PROVENT: Phase 3 study of efficacy and safety of AZD7442 (tixagevimab/cilgavimab) for pre-exposure prophylaxis of COVID-19 in adults. Open Forum Infect Dis 2021; 8: S810. https://doi.org/10.1093/ofid/ofab466.1646
6. Food and Drug Administration. Fact Sheet for Health Care Providers: Emergency Use Authorization for Evusheld (™) (tixagevimab co-packaged with cilgavimab). https://www.fda.gov/media/154701/download.
7. Mallapaty S. Fourth dose of COVID vaccine offers only slight boost against Omicron infeccion. Nature. 23 febrero 2022. Accessed 17 marzo 2022. https://www.nature.com/articles/d41586-022-00486-9
8. Hur K. Pfizer planning to submit data on 4th COVID shot soon, while working on vaccine for all variants. CNBC. 11 marzo 2022. https://www.cnbc.com/2022/03/11/pfizer-planning-to-submit-data-on-4th-covid-shot-soon-while-working-on-vaccine-for-all-variants.html
9. Zimmer C. ‘Stealth’ Omicron es stealthy no more: what’s known about the BA.2 variant. NY Times. 17 marzo 2022. https://www.nytimes.com/article/omicron-variant-ba2.html
10. Yu J, Collier A, Rowe M, et al. Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 variants. NEJM. 16 march 2022. DOI: 10.1056/NEJMc2201849
11. Pérez-Then E, Luca C, Silva V. MonteiroImmunogenicity of heterologous BNT162b2 booster in fully vaccinated individuals with CoronaVac against SARS-CoV-2 variants Delta and Omicron: the Dominican Republic Experience. Preprint. 29 Dec 2021. doi: https://doi.org/10.1101/2021.12.27.21268459;
12. Ritchie H, Mathieu E, Rodes-Guirao L, et al. Hong Kong: Coronavirus pandemic country profile. In Our World Data. Accessed 17 marzo 2022. https://ourworldindata.org/coronavirus/country/hong-kong
13. Dolgin E. Omicron thwarts some of the world’s most-used COVID vaccines. Nature. 2022 Jan 13. https://www.nature.com/articles/d41586-022-00079-6
14. Christensen J. War in Ukraine could make the COVID-19 pandemic worse, WHO says. CNN Health. 14 marzo 2022. Accessed 17 marzo 2022. https://edition.cnn.com/2022/03/13/health/who-ukraine-war-covid-19/index.html
15. Alford
2. Mahase E. COVID-19: Pfizer’s paxlovid is 89% effective in patients at risk of serious illness, company reports. BMJ 2021; 375:n2713 DOI:10.1136/bmj.n2713. PMID 34750163
3.Gottlieb RL, Vaca CE, Paredes R, et al; GS-US-540-9012 (PINETREE) Investigators. Early remdesivir to prevent progression to severe Covid-19 in outpatients. N Engl J Med. Published online December 22, 2021. doi:10.1056/NEJMoa2116846 [PubMed 34937145]
4. Bernal AJ, Gomes da Silva MM, Musungaie DB, et al. Molnupiravir for oral Treatment of COVID-19 in non-hospitalized patients. N Engl J Med 2021. Published online ahead of print. DOI: 10.1056/MEJMoa2116044. PMID 34914868
5. Levin MJ, Ustianowski A, De Wit S, et al. PROVENT: Phase 3 study of efficacy and safety of AZD7442 (tixagevimab/cilgavimab) for pre-exposure prophylaxis of COVID-19 in adults. Open Forum Infect Dis 2021; 8: S810. https://doi.org/10.1093/ofid/ofab466.1646
6. Food and Drug Administration. Fact Sheet for Health Care Providers: Emergency Use Authorization for Evusheld (™) (tixagevimab co-packaged with cilgavimab). https://www.fda.gov/media/154701/download.
7. Mallapaty S. Fourth dose of COVID vaccine offers only slight boost against Omicron infeccion. Nature. 23 febrero 2022. Accessed 17 marzo 2022. https://www.nature.com/articles/d41586-022-00486-9
8. Hur K. Pfizer planning to submit data on 4th COVID shot soon, while working on vaccine for all variants. CNBC. 11 marzo 2022. https://www.cnbc.com/2022/03/11/pfizer-planning-to-submit-data-on-4th-covid-shot-soon-while-working-on-vaccine-for-all-variants.html
9. Zimmer C. ‘Stealth’ Omicron es stealthy no more: what’s known about the BA.2 variant. NY Times. 17 marzo 2022. https://www.nytimes.com/article/omicron-variant-ba2.html
10. Yu J, Collier A, Rowe M, et al. Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 variants. NEJM. 16 march 2022. DOI: 10.1056/NEJMc2201849
11. Pérez-Then E, Luca C, Silva V. MonteiroImmunogenicity of heterologous BNT162b2 booster in fully vaccinated individuals with CoronaVac against SARS-CoV-2 variants Delta and Omicron: the Dominican Republic Experience. Preprint. 29 Dec 2021. doi: https://doi.org/10.1101/2021.12.27.21268459;
12. Ritchie H, Mathieu E, Rodes-Guirao L, et al. Hong Kong: Coronavirus pandemic country profile. In Our World Data. Accessed 17 marzo 2022. https://ourworldindata.org/coronavirus/country/hong-kong
13. Dolgin E. Omicron thwarts some of the world’s most-used COVID vaccines. Nature. 2022 Jan 13. https://www.nature.com/articles/d41586-022-00079-6
14. Christensen J. War in Ukraine could make the COVID-19 pandemic worse, WHO says. CNN Health. 14 marzo 2022. Accessed 17 marzo 2022. https://edition.cnn.com/2022/03/13/health/who-ukraine-war-covid-19/index.html
15. Alford
Published
2022-03-28
How to Cite
1.
Gaus D. Covid 19 update: outpatient therapy and variants. PFR [Internet]. 2022Mar.28 [cited 2024Nov.23];7(1). Available from: https://practicafamiliarrural.org/index.php/pfr/article/view/231
Section
Artículos de revisión
